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[亚洲恶性疟原虫对氯喹和乙胺嘧啶-磺胺多辛联合用药的多重耐药性。关于1例新病例]

[Polyresistance of asiatic P. falciparum to chloroquine and pyrimethamine-sulfadoxine combination. Apropos of a new case].

作者信息

Pays J F, Hugues F C

出版信息

Bull Soc Pathol Exot Filiales. 1981 Jul-Aug;74(4):406-13.

PMID:7028296
Abstract

The authors report a case of a multi-drug resistant Asiatic P. falciparum strain in a first non-immune man treated out of an endemic zone after failure of chemoprophylaxis by pyrimethamine-sulfadoxine. The authors compare this care with the lately published cases in Germany and Switzerland. They call again that I and II resistances were observed at the time of the drug's trials in and out of endemic zones. They ascertain that this resistances are often associated with chloroquino-resistance and that their number increases chiefly in certain areas.

摘要

作者报告了一例耐多药的亚洲恶性疟原虫菌株感染病例,该病例发生在一名首次前往非流行区的非免疫男性身上,此人在接受乙胺嘧啶-磺胺多辛化学预防失败后发病。作者将该病例与德国和瑞士最近公布的病例进行了比较。他们再次指出,在药物试验期间,无论是在流行区内还是流行区外,都观察到了I型和II型耐药情况。他们确定,这些耐药性通常与氯喹耐药性相关,并且其数量主要在某些地区增加。

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