Pays J F, Hugues F C
Bull Soc Pathol Exot Filiales. 1981 Jul-Aug;74(4):406-13.
The authors report a case of a multi-drug resistant Asiatic P. falciparum strain in a first non-immune man treated out of an endemic zone after failure of chemoprophylaxis by pyrimethamine-sulfadoxine. The authors compare this care with the lately published cases in Germany and Switzerland. They call again that I and II resistances were observed at the time of the drug's trials in and out of endemic zones. They ascertain that this resistances are often associated with chloroquino-resistance and that their number increases chiefly in certain areas.
作者报告了一例耐多药的亚洲恶性疟原虫菌株感染病例,该病例发生在一名首次前往非流行区的非免疫男性身上,此人在接受乙胺嘧啶-磺胺多辛化学预防失败后发病。作者将该病例与德国和瑞士最近公布的病例进行了比较。他们再次指出,在药物试验期间,无论是在流行区内还是流行区外,都观察到了I型和II型耐药情况。他们确定,这些耐药性通常与氯喹耐药性相关,并且其数量主要在某些地区增加。