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促性腺激素释放激素抑制体外培养的垂体细胞对[3H]胸腺嘧啶核苷的摄取。

LHRH inhibits [3H]thymidine incorporation by pituitary cells cultured in vitro.

作者信息

Stepień H

出版信息

Endocrinology. 1981 Nov;109(5):1784-6. doi: 10.1210/endo-109-5-1784.

DOI:10.1210/endo-109-5-1784
PMID:7028467
Abstract

The effects of two synthetic neuropeptides, LHRH and neurotensin, on tritiated thymidine uptake by dispersed anterior pituitary cells were investigated. It was found that LHRH but not neurotensin (at concentrations between 10(-7) - 10(-11) M) inhibits incorporation of [3H]thymidine into DNA of pituitary cell nuclei, in a dose-dependent manner. These results indicate that LHRH can regulate not only secretory activity of the gonadotrophic cells but also can be involved in the control of anterior pituitary cell replication.

摘要

研究了两种合成神经肽，即促黄体生成素释放激素（LHRH）和神经降压素，对分散的垂体前叶细胞摄取氚化胸腺嘧啶核苷的影响。结果发现，LHRH（而非神经降压素，浓度在10^(-7) - 10^(-11) M之间）能以剂量依赖的方式抑制[3H]胸腺嘧啶核苷掺入垂体细胞核的DNA中。这些结果表明，LHRH不仅可以调节促性腺细胞的分泌活性，还可能参与垂体前叶细胞复制的控制。

相似文献

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LHRH inhibits [3H]thymidine incorporation by pituitary cells cultured in vitro.促性腺激素释放激素抑制体外培养的垂体细胞对[3H]胸腺嘧啶核苷的摄取。
Endocrinology. 1981 Nov;109(5):1784-6. doi: 10.1210/endo-109-5-1784.
2
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Relationship between release of LH and incorporation of tritiated thymidine in the anterior pituitary gland of the castrated male rat: effect of LHRH and its highly active analogue buserelin.去势雄性大鼠垂体前叶中促黄体生成素释放与氚标记胸腺嘧啶核苷掺入之间的关系：促性腺激素释放激素及其高活性类似物布舍瑞林的作用
Horm Metab Res. 1986 Jan;18(1):31-3. doi: 10.1055/s-2007-1012218.
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Relationship between release of LH and incorporation of tritiated thymidine in the anterior pituitary gland of the castrated female rat.去势雌性大鼠垂体前叶中促黄体生成素释放与氚标记胸腺嘧啶核苷掺入之间的关系。
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Effect of LHRH on incorporation of [32P]-orthophosphate into phosphatidylinositol by dispersed anterior pituitary cells.促黄体生成素释放激素对分散的垂体前叶细胞将[32P] - 正磷酸盐掺入磷脂酰肌醇的影响。
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Effect of hypothalamic extracts on the incorporation of [3H]-thymidine by pituitary cells in culture.下丘脑提取物对培养的垂体细胞摄取[3H] - 胸腺嘧啶核苷的影响。
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Neuropeptide-Y enhances luteinizing hormone (LH)-releasing hormone-induced LH release and elevations in cytosolic Ca2+ in rat anterior pituitary cells: evidence for involvement of extracellular Ca2+ influx through voltage-sensitive channels.神经肽Y增强促黄体生成素（LH）释放激素诱导的大鼠垂体前叶细胞LH释放及胞质Ca2+升高：通过电压敏感性通道的细胞外Ca2+内流参与的证据。
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The luteinizing hormone-releasing hormone (LHRH)-desensitized rat pituitary: luteinizing hormone responsiveness to LHRH in vitro.促黄体生成激素释放激素（LHRH）脱敏大鼠垂体：体外促黄体生成激素对LHRH的反应性
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Inhibition of luteinizing hormone release by analogs of luteinizing hormone-releasing hormone (LHRH) in vitro.促黄体生成激素释放激素（LHRH）类似物在体外对促黄体生成激素释放的抑制作用。
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引用本文的文献

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Quantification of the cellular proliferation on freshly dispersed cells from rat anterior pituitaries after in vivo and in vitro labelling with bromodeoxyuridine.用溴脱氧尿苷进行体内和体外标记后，对大鼠垂体前叶新鲜分散细胞的细胞增殖进行定量分析。
Histochem J. 1992 Mar;24(3):137-43. doi: 10.1007/BF01047463.