Chin H P, Atkins C E, Barndt R
Horm Metab Res. 1981 Sep;13(9):486-91. doi: 10.1055/s-2007-1019313.
Insulin secretion after intravenous administration of glucose was studied in fourteen dogs, twelve of which were four years of age or older. Based on several characteristics of insulin secretion kinetics, normal and impaired insulin responses were defined in the experimental subjects. Among those, five exhibited a marked depression of the initial stage of insulin release which was followed by a stage of relative hyperinsulinemia. Similarities between canine and human insulin secretion patterns were noted, and the potential usefulness of the procedure for the early detection of canine diabetes mellitus discussed.
对14只狗静脉注射葡萄糖后的胰岛素分泌情况进行了研究，其中12只狗年龄在4岁及以上。根据胰岛素分泌动力学的几个特征，在实验对象中定义了正常和受损的胰岛素反应。其中，5只狗在胰岛素释放的初始阶段表现出明显的抑制，随后是相对高胰岛素血症阶段。注意到犬类和人类胰岛素分泌模式之间的相似性，并讨论了该程序在早期检测犬类糖尿病方面的潜在用途。
