Quitkin F M, McGrath P, Liebowitz M R, Stewart J, Howard A
J Clin Psychopharmacol. 1981 Mar;1(2):70-4. doi: 10.1097/00004714-198103000-00005.
Clinical lore suggests that monoamine oxidase inhibitors (MAOIs) are not effective in endogenous depression. A review of previous placebo-controlled trials of MAOI in patients with endogenous depression neither refutes nor confirms their utility in this patient group. We present patients in the depressive phase of bipolar illness refractory to treatment with tricyclics who have responded to MAOI. These open trials require confirmation in controlled studies. Bipolar illness may be a heterogeneous disorder. Presence or absence of X-linkage, low platelet MAO, or response to MAOI may indicate different forms of the disorder.
临床经验表明，单胺氧化酶抑制剂（MAOIs）对内源性抑郁症无效。回顾先前针对内源性抑郁症患者进行的MAOI安慰剂对照试验，既未反驳也未证实其在该患者群体中的效用。我们报告了双相情感障碍抑郁期患者，他们对三环类药物治疗无效，但对MAOI有反应。这些开放试验需要在对照研究中得到证实。双相情感障碍可能是一种异质性疾病。X连锁的存在与否、低血小板MAO或对MAOI的反应可能表明该疾病的不同形式。
