Kirkpatrick J R, Dahn M
J Trauma. 1981 Nov;21(11):925-30.
Major alterations in the glucose-mediated regulation of growth hormone are associated with sepsis; however, these alterations are not related to the rate of change in plasma glucose or changes in glucagon, epinephrine levels, or circulating levels of arginine. Alterations in the growth hormone regulatory mechanism occurred among septic patients who manifested severe glucose intolerance which was associated with suppression of insulin production. Inhibition of growth hormone release in these patients may have an adverse effect on amino acid movement, which lends further support to the concept that sustained hyperglycemia in the septic patient is undesirable.
葡萄糖介导的生长激素调节的重大改变与脓毒症相关；然而，这些改变与血浆葡萄糖的变化率或胰高血糖素、肾上腺素水平或精氨酸循环水平的变化无关。生长激素调节机制的改变发生在表现出严重葡萄糖不耐受且与胰岛素分泌受抑制相关的脓毒症患者中。这些患者生长激素释放的抑制可能对氨基酸转运产生不利影响，这进一步支持了脓毒症患者持续高血糖是不可取的这一观点。
