Kambara H, Yoshida A, Kawashita K, Kawai C
Jpn Circ J. 1981 Oct;45(10):1158-63. doi: 10.1253/jcj.45.1158.
To determine the therapeutic effects of glucose-insulin-potassium (GIK) solution, 5 control dogs and 5 GIK-treated dogs were investigated 24 hours after coronary artery occlusion by use of myocardial creatine phosphokinase (CK) activity and myocardial thallium-201 uptake. There was no significant difference in myocardial blood flow estimated by thallium-201 uptake between the control and the GIK group, but myocardial CK activity in the ischemic zone of GIK-treated animals was significantly higher than that of the control group. This suggests that administration of GIK solution is effective in protecting myocardial tissue in the central ischemic area and that this protecting action of GIK seems to be independent of myocardial blood flow.
为了确定葡萄糖-胰岛素-钾（GIK）溶液的治疗效果，在冠状动脉闭塞24小时后，通过使用心肌肌酸磷酸激酶（CK）活性和心肌铊-201摄取情况，对5只对照犬和5只接受GIK治疗的犬进行了研究。通过铊-201摄取估算的心肌血流量在对照组和GIK组之间没有显著差异，但接受GIK治疗动物的缺血区心肌CK活性显著高于对照组。这表明给予GIK溶液对保护中心缺血区域的心肌组织有效，并且GIK的这种保护作用似乎与心肌血流量无关。
