Ghavimi F, Exelby P R, Jereb B, Lieberman P H, Scott B F, Kosloff C
Natl Cancer Inst Monogr. 1981 Apr(56):103-9.
Twenty-eight previously untreated patients with embryonal rhabdomyosarcoma, stages II to IV, were treated with the T-6 induction protocol and maintained on the T-2 protocol. The T-6 protocol consisted of simultaneous administration of drugs and irradiation, given in 3 parts each separated by an obligatory period of rest. Twenty-four of the 28 patients (85.7%) survived 4 to 44 months, with a median follow-up of 24 months; 18 (64%) have been in continuous disease-free status. The immediate toxicity of the T-6 induction was severe and required intensive supportive care. To date, the results from the T-6 induction protocol were more effective than those achieved with the T-2 protocol.
28例之前未接受过治疗的Ⅱ至Ⅳ期胚胎性横纹肌肉瘤患者接受了T-6诱导方案治疗，并采用T-2方案维持治疗。T-6方案包括药物与放疗同时进行，分3个部分，每部分之间有一段规定的休息期。28例患者中有24例（85.7%）存活了4至44个月，中位随访时间为24个月；18例（64%）处于持续无病状态。T-6诱导治疗的即刻毒性严重，需要强化支持治疗。迄今为止，T-6诱导方案的治疗结果比T-2方案更有效。
