Vitali M L, Ricci G, Acquaviva A, Neri E, Cominetti M, Tomassini E, Boni L, Rasore-Quartino A, Bistolfi F, De Bernardi B
Servizio di Radioterapia, E.O. Ospedali Galliera, Genova, Italia.
Pediatr Med Chir. 1993 May-Jun;15(3):279-85.
The authors retrospectively analyzed the therapy results in a large group of children affected by rhabdomyosarcoma and treated from 1978 to 1988 with chemotherapy, radiotherapy and surgery. 39/58 patients (67%) achieved a complete response and 25/39 maintained the NED status. An individualized treatment was given to 13 patients who relapsed, but only 3 of them obtained a second response. Those with primary tumor in the orbit or in the genito-urinary tract had lower recurrence rate than patients with head and neck, extremities, pelvis and trunk diseases. Patients in clinical group I and II (according with I.R.S. stadiation) had a significantly better survival than those with more advanced disease (clinical groups III and IV). Relatively to the primary site of the disease, the late effects of combined treatment are mentioned.
作者回顾性分析了1978年至1988年期间接受化疗、放疗和手术治疗的一大组横纹肌肉瘤患儿的治疗结果。58例患者中有39例（67%）获得完全缓解，39例中有25例维持无疾病证据状态。对13例复发患者给予了个体化治疗，但其中只有3例获得了二次缓解。眼眶或泌尿生殖道原发性肿瘤患者的复发率低于头颈部、四肢、骨盆和躯干疾病患者。根据国际横纹肌肉瘤研究组（IRS）分期，I期和II期临床患者的生存率明显高于疾病进展更严重的患者（III期和IV期临床组）。文中提到了联合治疗相对于疾病原发部位的晚期效应。
