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The regulation of eIF-2 function protein synthesis initiation.

作者信息

Safer B, Jagus R

出版信息

Biochimie. 1981 Aug-Sep;63(8-9):709-17. doi: 10.1016/s0300-9084(81)80219-2.

DOI:10.1016/s0300-9084(81)80219-2
PMID:7030409
Abstract

The regulation of eIF-2 activity during protein synthesis initiation has been postulated to involve phosphorylation/dephosphorylation mechanisms and/or the participation of ancillary protein factors. Both mechanisms would affect directly the binding of initiator methionyl-tRNAi by eIF-2. Recent data concerning the phosphorylation state of eIF-2 in hemin-deficient lysates and other covalent modifications which alter the efficiency of eIF-2 utilization, however, suggest that modulation of eIF-2 activity is more complex, and involves alteration of its catalytic recycling.

摘要

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