Bower D J, Hart R J, Matthews P A, Howden M E
Clin Toxicol. 1981 Jul;18(7):813-63. doi: 10.3109/15563658108990310.
Nonprotein neurotoxins are continuing to play a major role as molecular probes in studying nervous processes. They also have clinical importance as some of them, such as saxitoxin and its analogues, are the source of public health problems, or have potential use in therapy. This review covers clinical, biological, pharmacological, and chemical aspects of certain nonprotein neurotoxins, with emphasis on three well-known ones: tetrodotoxin, saxitoxin, and batrachotoxin. The distribution of the toxins is discussed as well as their symptomatology, treatment of affected patients, and effects of their structures on their physiological activity. With so many outstanding problems remaining in neuropharmacology, the study of nonprotein neurotoxins thrives as a fertile area of research.
非蛋白质神经毒素在研究神经过程中作为分子探针继续发挥着重要作用。它们还具有临床重要性，因为其中一些毒素，如石房蛤毒素及其类似物，是公共卫生问题的根源，或者在治疗方面具有潜在用途。本综述涵盖了某些非蛋白质神经毒素的临床、生物学、药理学和化学方面，重点介绍了三种著名的毒素：河豚毒素、石房蛤毒素和箭毒蛙毒素。文中讨论了这些毒素的分布、症状、对受影响患者的治疗以及它们的结构对其生理活性的影响。由于神经药理学中仍存在许多突出问题，非蛋白质神经毒素的研究作为一个富有成果的研究领域蓬勃发展。
