Nievel J G, Harvard C W
Curr Med Res Opin. 1981;7(8):503-15. doi: 10.1185/03007998109112365.
The antihypertensive effect of slow-release metoprolol was studied in 50 patients suffering from mild to moderate essential hypertension. In a double-blind crossover study, the effect of slow-release metoprolol was compared with conventional metoprolol for efficacy and tolerability in 40 patients. After a 2-week period on placebo, patients received either 200 mg slow-release metoprolol once daily or 200 mg conventional metoprolol once daily for 6 weeks before crossing over to the alternative dosage form for a further 6 weeks. The results showed that both slow-release and conventional metoprolol were equipotent and reduced significantly the pulse rate and also the supine, sitting and standing systolic and diastolic blood pressures. Slow-release metoprolol also reduced the exercise blood pressure in 10 patients following 2-weeks' administration of 200 mg daily in a single dose. Good patient compliance with the medication was observed. No adverse effect attributable to slow-release metoprolol or conventional metoprolol was detected throughout the study.
对50例轻至中度原发性高血压患者研究了缓释美托洛尔的降压效果。在一项双盲交叉研究中，比较了40例患者使用缓释美托洛尔和传统美托洛尔的疗效及耐受性。在服用安慰剂2周后，患者每日一次服用200mg缓释美托洛尔或200mg传统美托洛尔，持续6周，之后交叉使用另一种剂型再持续6周。结果显示，缓释美托洛尔和传统美托洛尔疗效相当，均能显著降低脉率以及仰卧位、坐位和站立位的收缩压与舒张压。在10例患者中，每日单次服用200mg缓释美托洛尔2周后，运动血压也有所降低。观察到患者对药物的依从性良好。在整个研究过程中，未检测到与缓释美托洛尔或传统美托洛尔相关的不良反应。
