[Use of DNA antibodies for detecting DNA radiation injuries in the bone marrow cell nuclei of irradiated animals].

Impairments in DNA from brain stem cell nuclei of X-ray irradiated animals were studied at early steps after irradiation using antibodies to single-stranded DNA. A possibility was shown to detect by means of an immunochemical technique the irradiation-induced impairments of DNA in brain stem cells. Detection of the impairment was possible within 3 hrs after high doses of the irradiation (206.4-258 mCi/kg); after lower doses - within the first hour of the postirradiation period. The immunochemical procedure might be used for early biological detection of the irradiation impairments as well as for estimation of radio-sensitivity of nuclear cells to the effects of irradiation and radioprotectors.