Ten Have-Opbroek A A
Am J Anat. 1981 Nov;162(3):201-19. doi: 10.1002/aja.1001620303.
To evaluate one model of mammalian-lung development, i.e., division into periods, pre- and postnatal lung development in the CPB-S mouse strain was divided into the currently distinguished periods: the pseudoglandular period, covering establishment of the air-conducting portion; and the canalicular, terminal-sac, and alveolar or postnatal periods, in which the respiratory portion develops. The last three periods would each cover the formation of a different component of the respiratory unit or pulmonary acinus (acinus pulmonaris) (nonalveolated respiratory bronchiole, nonalveolated duct and sac, and alveolar pouch). However, determination of the nature of the relevant structures on the basis of recent findings concerning the epithelia showed that these hypotheses are not tenable. Since the tubule with cuboidal epithelium (appearing in the pseudoglandular and following periods) is the basic structure in the genesis of the pulmonary acinus, the development of the respiratory portion must start in the pseudoglandular period. Likewise, since the definitive components of the acinus are derived from this acinar tubule, their establishment may not be restricted to one of the other periods. Because other postulated divisions of mammalian-lung development were based on similar histological interpretations, they cannot reflect the course of mouse-lung development either. Therefore, a developmental scheme based on the recent findings concerning the epithelia is given as well as a tentative scheme for the human lung. The respiratory portion proved to develop by budding of acinar tubules, the mode of budding being not restricted to any particular pattern.
为了评估一种哺乳动物肺发育模型，即划分为不同时期，CPB-S小鼠品系的产前和产后肺发育被划分为当前区分的时期：假腺期，涵盖导气部分的建立；以及细支气管、终末囊和肺泡或产后时期，呼吸部分在这些时期发育。后三个时期分别涵盖呼吸单位或肺腺泡（肺腺泡）不同组成部分的形成（非肺泡化呼吸性细支气管、非肺泡化导管和囊以及肺泡囊）。然而，根据最近关于上皮细胞的研究结果确定相关结构的性质表明，这些假设是站不住脚的。由于具有立方上皮的小管（出现在假腺期及之后的时期）是肺腺泡发生的基本结构，呼吸部分的发育必须始于假腺期。同样，由于腺泡的最终组成部分源自该腺泡小管，它们的建立可能不限于其他时期之一。因为哺乳动物肺发育的其他假定划分是基于类似的组织学解释，所以它们也不能反映小鼠肺发育的过程。因此，给出了基于最近关于上皮细胞研究结果的发育方案以及人类肺的暂定方案。事实证明，呼吸部分是通过腺泡小管的出芽发育而来的，出芽方式不限于任何特定模式。
