Kramer J L, Bell M J, DeSchryver K, Bower R J, Ternberg J L, White N H
Am J Surg. 1982 Jan;143(1):116-9. doi: 10.1016/0002-9610(82)90140-4.
Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreases revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.
9名患有胰岛细胞增殖症的儿童在圣路易斯儿童医院接受了胰腺切除术。其中4名儿童接受了近全切除术，切除率达99%。术后只有1名儿童需要长期胰岛素治疗。对切除的胰腺进行病理检查发现胰腺结构弥漫性紊乱。长期低血糖会导致严重的神经后遗症。基于临床经验以及受累胰腺弥漫性病变的病理表现，提倡近全胰腺切除术（99%）作为该病的首选主要术式。
