DiMagno E P, Shorter R G, Taylor W F, Go V L
Cancer. 1982 Jan 15;49(2):361-8. doi: 10.1002/1097-0142(19820115)49:2<361::aid-cncr2820490225>3.0.co;2-o.
To determine whether ductal or parenchymal histologic abnormalities were related to the type of openings of the pancreatic duct and common bile duct into the duodenum, 390 unfixed human postmortem en bloc pancreaticoduodenal specimens were examined anatomically, radiographically, and histologically. In 353 specimens, ductal openings were classifiable: 25% had a well-defined ampulla, 18% a long common channel, 31% a short common channel, 7% an interposed septum, and 19% had separate openings for the pancreatic and bile ducts. Ductal histologic abnormalities were present in 25% of the specimens and most (77%) were found in the pancreatic head. When ductal openings were grouped according to the presence or lack of a prominent common channel, ductal epithelial abnormalities were more common in the absence of a prominent common channel (30% vs. 19%, p less than 0.04). Papillary epithelial hyperplasia was associated only with the absence of a prominent common channel (P = 0.02). Histologic abnormalities were more common in the elderly (P less than 0.005) but were not associated with cause of death or the presence of the minor pancreatic duct. Lack of a common channel is associated with abnormal ductal epithelium. This anatomic arrangement may be a factor in pancreatic carcinogenesis.
为了确定导管或实质组织学异常是否与胰管和胆总管进入十二指肠的开口类型有关，对390例未固定的人类尸检整块胰十二指肠标本进行了解剖学、影像学和组织学检查。在353例标本中，导管开口可分类：25%有明确的壶腹，18%有长共同通道，31%有短共同通道，7%有插入隔膜，19%胰管和胆管开口分开。25%的标本存在导管组织学异常，大多数（77%）见于胰头。当根据是否存在明显的共同通道对导管开口进行分组时，在没有明显共同通道的情况下，导管上皮异常更为常见（30%对19%，P<0.04）。乳头上皮增生仅与没有明显共同通道有关（P = 0.02）。组织学异常在老年人中更常见（P<0.005），但与死亡原因或副胰管的存在无关。缺乏共同通道与导管上皮异常有关。这种解剖结构可能是胰腺癌发生的一个因素。
