De Ponti C, De Biase A M, Pirelli S, Cataldo G, Salvadé P, Lanocita M, Carù B
Cardiology. 1981;68 Suppl 2:195-9.
The action of nifedipine (N), acebutolol (A), and their association (A+N) was studied in 16 patients suffering from effort angina with documented coronary artery disease. The therapeutic action was valued by bicycle effort stress test after oral administration of medications in comparison with placebo (P), following a double-blind random sequence of treatments. Working capacity significantly increased after A (507 +/- 450 mkp, p less than 0.05), after N (1,140 +/- 767 mkp, p less than 0.001), and after A+N (1,198 +/- 644 mkp, p less than 0.01). The increments of work after P administration were not significant. Moreover, fatigue instead of angina appeared as a stopping criterion in 8 patients after A+N, and in only 1 patient after P, A, and N.
对16例经证实患有冠状动脉疾病的劳力性心绞痛患者，研究了硝苯地平（N）、醋丁洛尔（A）及其联合用药（A + N）的作用。按照双盲随机治疗顺序，在口服药物后，通过自行车运动负荷试验评估治疗效果，并与安慰剂（P）进行比较。服用A后工作能力显著提高（507±450 mkp，p＜0.05），服用N后（1140±767 mkp，p＜0.001），以及服用A + N后（1198±644 mkp，p＜0.01）。服用P后工作能力的增加不显著。此外，8例患者在服用A + N后，疲劳而非心绞痛成为终止运动的标准，而在服用P、A和N后，只有1例患者出现这种情况。
