促性腺激素释放激素类似物诱导垂体切除大鼠排卵涉及前列腺素。

Ovulation induced by a gonadotropin releasing hormone analog in hypophysectomized rats involves prostaglandins.

作者信息

Ekholm C, Clark M R, Magnusson C, Isaksson O, LeMaire W J

出版信息

Endocrinology. 1982 Jan;110(1):288-90. doi: 10.1210/endo-110-1-288.

Abstract

A potent analogue of gonadotropin releasing hormone [D-Ala6- Des-Gly10-NH2]-GnRH ethylamide (GnRHa) caused oocyte maturation and ovulation when injected in the afternoon of proestrus in immature PMSG-treated female rats, hypophysectomized on the morning of proestrus. This action of GnRHa was accompanied by a marked increase in ovarian PGE levels. Furthermore, the pretreatment of the animals with a prostaglandin synthetase inhibitor (indomethacin) completely inhibited this PGE increase and ovulation. These data suggest a role for prostaglandins in GnRHa induced ovulation.

摘要

一种促性腺激素释放激素的强效类似物[D-丙氨酸6-去甘氨酸10-乙酰胺]-促性腺激素释放激素类似物（GnRHa），在动情前期上午进行垂体切除的未成熟PMSG处理的雌性大鼠动情前期下午注射时，可引起卵母细胞成熟和排卵。GnRHa的这一作用伴随着卵巢PGE水平的显著升高。此外，用前列腺素合成酶抑制剂（吲哚美辛）对动物进行预处理可完全抑制这种PGE升高和排卵。这些数据表明前列腺素在GnRHa诱导的排卵中起作用。