De Moor M, Ooghe R
J Int Med Res. 1981;9(6):495-500. doi: 10.1177/030006058100900612.
Forty patients with osteoarthrosis or rheumatoid arthritis were entered in a 4-week double-blind trial to compare the efficacy, safety and tolerance of a flurbiprofen 100 mg suppository formulation with indomethacin 100 mg suppositories. There were twenty patients each on indomethacin and flurbiprofen. Statistically significant improvements were reported for both treatments during the study with respect to morning stiffness, night pain and the overall progress of the patients. Both treatments were equally effective with respect to the amount of improvement shown for the parameters. No improvement was noted on either treatment with respect to grip-strength, functional capacity or the daily intake of analgesic therapy, while a marginally significant decrease in the erythrocyte sedimentation rate was noted on indomethacin. Both treatments were well tolerated with only a few transient and mild side-effects being reported. On the basis of this trial, flurbiprofen and indomethacin suppositories have equal therapeutic effects in the treatment of night pain and morning stiffness.
40例骨关节炎或类风湿关节炎患者进入一项为期4周的双盲试验，以比较100毫克氟比洛芬栓剂与100毫克吲哚美辛栓剂的疗效、安全性和耐受性。吲哚美辛组和氟比洛芬组各有20例患者。研究期间，两种治疗方法在晨僵、夜间疼痛和患者总体病情进展方面均报告有统计学上的显著改善。两种治疗方法在参数改善程度方面同样有效。两种治疗方法在握力、功能能力或每日镇痛治疗摄入量方面均未观察到改善，而吲哚美辛治疗使红细胞沉降率略有显著下降。两种治疗方法耐受性良好，仅报告有少数短暂、轻微的副作用。基于该试验，氟比洛芬栓剂和吲哚美辛栓剂在治疗夜间疼痛和晨僵方面具有同等治疗效果。
