[New developments in cancer cytogenetics].

Three topics are discussed in the review: 1) The non-random and specific chromosome changes in human and animal tumors, 2) prezygotic chromosomal mutations which specifically predispose to some human tumors, and 3) the role of cytogenetics in the discovery and study of a novel phenomenon for mammalian cells-gene amplification which was revealed in a number of tumors and in cell lines resistant to some anticancer drugs.