Hidaka H, Nagulesparan M, Klimes I, Clark R, Sasaki H, Aronoff S L, Vasquez B, Rubenstein A H, Unger R H
J Clin Endocrinol Metab. 1982 Feb;54(2):217-22. doi: 10.1210/jcem-54-2-217.
Insulin secretion and insulin resistance were examined in seven obese type II diabetics before and after control of plasma glucose levels without weight loss. Control was achieved by regular insulin injection (60-205 U/day in four doses). After 10 days of therapy, plasma insulin and C-peptide responses to oral glucose were significantly improved. Insulin-induced glucose rates, estimated by the glucose clamp technique, averaged 1.08 +/- 0.30 mg/kg. min (mean +/- SEM; n = 7) before treatment and were unchanged (1.08 +/- 0.25) after treatment. These indicate that short term control of plasma glucose improved insulin secretion but not insulin sensitivity. The impaired insulin secretion and insulin sensitivity in type II diabetics appears to be, in part, secondary to metabolic abnormalities associated with hyperglycemia.
在7名肥胖的II型糖尿病患者中，在未减轻体重的情况下，于控制血糖水平前后对胰岛素分泌和胰岛素抵抗进行了检测。通过常规胰岛素注射（每天60 - 205单位，分4次注射）实现血糖控制。治疗10天后，口服葡萄糖后血浆胰岛素和C肽反应显著改善。通过葡萄糖钳夹技术估算的胰岛素诱导的葡萄糖输注率，治疗前平均为1.08±0.30毫克/千克·分钟（均值±标准误；n = 7），治疗后未改变（1.08±0.25）。这些结果表明，短期控制血糖可改善胰岛素分泌，但不能改善胰岛素敏感性。II型糖尿病患者受损的胰岛素分泌和胰岛素敏感性似乎部分继发于与高血糖相关的代谢异常。
