Puavilai G, Drobny E C, Domont L A, Baumann G
J Clin Endocrinol Metab. 1982 Feb;54(2):247-53. doi: 10.1210/jcem-54-2-247.
Pregnancy is accompanied, in its later stages, by physiological resistance to the action of insulin. We studied the potential contribution of altered insulin receptors to this phenomenon in 12 healthy pregnant women during their third trimester. For comparison, we studied the same women again several weeks postpartum. We also used a group of randomly chosen nonpregnant subjects as a control population. Women in this control group were studied during the luteal phase of the menstrual cycle. Plasma insulin and insulin to glucose ratios were significantly higher in the pregnant women. Insulin binding to peripheral blood monocytes was higher in pregnancy than postpartum in the majority of women, and as a group, the pregnant subjects showed significantly higher insulin binding than the nongravid subjects. This appeared to be due to a greater number of receptor sites per cell. We found no correlation between plasma insulin and insulin binding in pregnancy. We conclude that the insulin resistance of pregnancy is not attended by impaired binding of insulin to cellular receptors, at least in the monocyte. Our data suggest that the defect in insulin action lies at a site distal to the receptor.
妊娠后期会伴随着对胰岛素作用的生理抵抗。我们研究了12名健康孕妇在妊娠晚期胰岛素受体改变对这一现象的潜在影响。为作比较，我们在产后数周再次对这些女性进行了研究。我们还选取了一组随机的非孕受试者作为对照人群。对该对照组女性在月经周期的黄体期进行了研究。孕妇的血浆胰岛素和胰岛素与葡萄糖的比值显著更高。在大多数女性中，妊娠期间胰岛素与外周血单核细胞的结合高于产后，并且作为一个群体，妊娠受试者的胰岛素结合显著高于非妊娠受试者。这似乎是由于每个细胞的受体位点数量更多。我们发现妊娠期间血浆胰岛素与胰岛素结合之间没有相关性。我们得出结论，至少在单核细胞中，妊娠的胰岛素抵抗并不伴有胰岛素与细胞受体结合受损。我们的数据表明，胰岛素作用的缺陷位于受体远端的位点。
