Phillips R W, Westmoreland N, Panepinto L, Case G L
J Nutr. 1982 Jan;112(1):104-11. doi: 10.1093/jn/112.1.104.
Yucatan miniature swine have been selected for increased (high K) or decreased (low K) ability to utilize glucose based on an intravenous glucose tolerance test (IVGTT). In this study we tested the effect of obesity in conjunction with ad libitum, high sucrose or high starch diets on IVGTT and the insulin response to glucose in these two lines of animals. Either diet caused increased glucose utilization and an increased insulin response in the low K animals. Neither diet caused a change in these parameters in the high K pigs. There were no differences in either line of animals due to sucrose vs starch diets. During an insulin impedance test both the mean steady state plasma glucose and plasma serum insulin concentration were significantly higher in the high K animals (P less than 0.01).
基于静脉葡萄糖耐量试验（IVGTT），尤卡坦小型猪被选育出利用葡萄糖能力增强（高钾）或减弱（低钾）的品系。在本研究中，我们测试了肥胖与自由采食、高蔗糖或高淀粉饮食相结合对这两个品系动物的IVGTT以及葡萄糖的胰岛素反应的影响。两种饮食均使低钾动物的葡萄糖利用率增加且胰岛素反应增强。两种饮食均未使高钾猪的这些参数发生变化。蔗糖与淀粉饮食对两个品系的动物均无差异。在胰岛素抵抗试验中，高钾动物的平均稳态血浆葡萄糖和血浆胰岛素浓度均显著更高（P小于0.01）。
