Nielsen I M, Ellegaard B, Karring T
J Periodontol. 1981 Dec;52(12):723-8. doi: 10.1902/jop.1981.52.12.723.
The purpose of this investigation was to evaluate, in humans, the use of Kielbone as a substitute for fresh autogenous bone in treating periodontal intrabony defects. A total of 92 intrabony defects were treated with a previously described new attachment procedure utilizing free mucosal grafts to cover the intrabony defects following bone grafting. Kielbone was placed in 46 of these defects, while the remaining 46 defects were treated with autogenous bone grafts. The results were evaluated after 6 months by periodontal probing and assessment of the bone level as seen on periodical, identical radiographs. No differences were observed between the amount of clinical gain of attachment obtained in defects treated with Kielbone and those treated with autogenous jaw bone. This indicates that in surgical procedures attempting to restore lost connective tissue attachment, Kielbone constitutes a suitable replacement for fresh autogenous bone. The results are discussed in th light of recent studies that challenge the beneficial effect of bone grafts in the treatment of intrabony defects.
本研究的目的是在人体中评估使用基尔骨替代新鲜自体骨治疗牙周骨内缺损的效果。总共92例骨内缺损采用先前描述的新附着程序进行治疗，该程序在骨移植后利用游离黏膜移植覆盖骨内缺损。其中46例缺损植入基尔骨，其余46例缺损采用自体骨移植治疗。6个月后通过牙周探诊和定期拍摄的相同X光片评估骨水平来评价结果。在植入基尔骨治疗的缺损和植入自体颌骨治疗的缺损中，获得的附着临床增益量未观察到差异。这表明在试图恢复失去的结缔组织附着的外科手术中，基尔骨可作为新鲜自体骨的合适替代品。结合最近对骨移植治疗骨内缺损有益效果提出质疑的研究对结果进行了讨论。
