Bacia T, Purska-Rowińska E, Okuszko S
Monogr Neural Sci. 1980;5:153-9. doi: 10.1159/000387498.
One hundred sixty one epileptic patients, resistant to standard antiepileptic medication, were treatecd with clonazepam. In 19 cases clonazepam was given during the epileptic status. In 17 cases the status was stopped. In the remaining 142 patients clonazepam was given orally. The short term effect of the drug was analysed after 3 months of observation and the long term effect after a period of more than 1 year of observation. The authors compare the relationship between the clinical form of epilepsy, the EEG changes and the duration of disease with the long and short term therapeutic effect of clonazepam. The results obtained suggest: short term therapy is more successful than long term therapy, poor results or intolerance at the beginning of the treatment occur in about 20% of patients. The influence of clonazepam on epilepsy with focal seizures is relatively better than on generalized forms of epilepsy. "Old" cases of epilepsy are significantly more resistant to clonazepam medication. The same is true for diffuse brain damage.
161例对标准抗癫痫药物耐药的癫痫患者接受了氯硝西泮治疗。19例在癫痫持续状态时给予氯硝西泮。17例癫痫持续状态得到控制。其余142例患者口服氯硝西泮。观察3个月后分析药物的短期疗效，观察1年以上后分析长期疗效。作者比较了癫痫的临床类型、脑电图变化、病程与氯硝西泮的长期和短期治疗效果之间的关系。所得结果表明：短期治疗比长期治疗更成功，约20%的患者在治疗开始时效果不佳或不耐受。氯硝西泮对局灶性癫痫发作的影响相对比对全身性癫痫形式的影响更好。癫痫“病程长”的病例对氯硝西泮治疗的耐药性明显更高。弥漫性脑损伤的情况也是如此。
