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丁咯地尔与己酮可可碱治疗动脉闭塞性疾病疗效的对比评估

Comparative evaluation of the effectiveness of buflomedil and pentoxifylline in patients with arterial occlusive disease.

作者信息

Trübestein G, Trübestein R, Duong Q D

出版信息

Angiology. 1981 Oct;32(10):705-10. doi: 10.1177/000331978103201006.

DOI:10.1177/000331978103201006
PMID:7034591
Abstract

A double-blind study was performed on 40 physically trained patients with stage II peripheral arterial insufficiency. Daily doses of 450 mg buflomedil were administered for 90 days and eventual improvements were compared to the effects of pentoxifylline given in daily doses of 300 mg. After treatment with buflomedil and also with pentoxifylline, significant increases were achieved in walking distances during these tests, the increase was not significant. Nor uniform findings were noted in oscillograms and in ultrasonic Doppler investigations.

摘要

对40例患有II期外周动脉供血不足的体能训练患者进行了一项双盲研究。每天给予450毫克丁咯地尔,持续90天,并将最终改善情况与每天给予300毫克己酮可可碱的效果进行比较。在使用丁咯地尔和己酮可可碱治疗后,这些测试中的步行距离显著增加,但增加并不显著。在示波图和超声多普勒检查中也未发现一致的结果。

相似文献

1
Comparative evaluation of the effectiveness of buflomedil and pentoxifylline in patients with arterial occlusive disease.丁咯地尔与己酮可可碱治疗动脉闭塞性疾病疗效的对比评估
Angiology. 1981 Oct;32(10):705-10. doi: 10.1177/000331978103201006.
2
[Training by walking and drug therapy of peripheral arterial occlusive disease].[外周动脉闭塞性疾病的步行训练与药物治疗]
Vasa Suppl. 1987;20:384-7.
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Pentoxifylline (Trental)--a new drug for the treatment of peripheral chronic occlusive arterial disease.
J Med. 1988;19(2):89-107.
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[Treatment of circulation disorders with pentoxifylline. A double-blind study with Trental].
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Beneficial hemorheologic therapy of chronic peripheral arterial disorders with pentoxifylline: results of double-blind study versus vasodilator-nylidrin.
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[Treatment of chronic obliterative arteriopathy of the legs in the second Fontaine's stage. Personal experience with a buflomedil-pentoxifylline-defibrotide combination].[法安明、己酮可可碱、去纤苷联合治疗法廷二期下肢慢性闭塞性动脉病。个人经验]
Clin Ter. 1995 Mar;146(3):211-4.
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[Drug therapy of arterial diseases. A study with Trental 400].
Fortschr Med. 1980 Dec 4;98(45):1795-8.
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Buflomedil in arterial occlusive disease: results of a controlled multicenter study.丁咯地尔治疗动脉闭塞性疾病:一项对照多中心研究的结果。
Angiology. 1984 Aug;35(8):500-5. doi: 10.1177/000331978403500805.
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Intravenous treatment of chronic peripheral occlusive arterial disease: a double-blind, placebo-controlled, randomized, multicenter trial of pentoxifylline.
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Comparative evaluation of pentoxifylline, buflomedil, and nifedipine in the treatment of intermittent claudication of the lower limbs.己酮可可碱、丁咯地尔和硝苯地平治疗下肢间歇性跛行的比较评价
Angiology. 1994 Jul;45(7):647-53. doi: 10.1177/000331979404500708.

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Pentoxifylline (oxpentifylline). A review of its therapeutic efficacy in the management of peripheral vascular and cerebrovascular disorders.
己酮可可碱(氧代己酮可可碱)。对其治疗外周血管疾病和脑血管疾病疗效的综述。
Drugs Aging. 1995 Dec;7(6):480-503. doi: 10.2165/00002512-199507060-00007.
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Buflomedil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in peripheral and cerebral vascular diseases.丁咯地尔。对其药效学和药代动力学特性以及在周围血管疾病和脑血管疾病中的治疗效果的综述。
Drugs. 1987 May;33(5):430-60. doi: 10.2165/00003495-198733050-00002.