Stewart R H, Kimbrough R L, Martin P A, Ward R L, Smith J P
Ann Ophthalmol. 1981 Nov;13(11):1279-83.
Norepinephrine dipivalylate, a prodrug analog of the catecholamine mediator norepinephrine, was given to 12 ocular hypertensive patients. Single instillations of four concentrations, 0.05%, 0.1%, 0.25%, and 0.5%, were administered weekly to one eye only with the fellow eye receiving a placebo. Intraocular pressure, pupil size, ocular signs, subjective symptoms, heart rate, and blood pressure were monitored at 2, 4, 6, 8, and 12 hours following instillation. An intraocular pressure reduction dose response was seen. After a slow (four-hour) onset of activity, the 0.5% concentration produced clinically acceptable (less than 22 mm Hg) tensions at the 6-, 8-, and 12-hour observations which were significantly (p less than 0.05, paired t test) lower than placebo-control eyes. No clinically important side effects were seen.
去甲肾上腺素二特戊酸酯是儿茶酚胺介质去甲肾上腺素的一种前药类似物，被给予12名高眼压患者。每周仅对一只眼睛单次滴注四种浓度（0.05%、0.1%、0.25%和0.5%），另一只眼睛接受安慰剂。在滴注后2、4、6、8和12小时监测眼压、瞳孔大小、眼部体征、主观症状、心率和血压。观察到眼压降低的剂量反应。在缓慢（4小时）起效后，0.5%浓度在6、8和12小时观察时产生了临床上可接受的（低于22 mmHg）眼压，显著（p<0.05，配对t检验）低于安慰剂对照眼。未观察到具有临床重要意义的副作用。
