Binder P S, Beal J P, Zavala E Y
Arch Ophthalmol. 1982 Jan;100(1):101-5. doi: 10.1001/archopht.1982.01030030103009.
We studied a human cornea that was obtained at the time of penetrating keratoplasty four months after a keratophakia procedure and cataract extraction. We found endothelial cell loss with corneal edema, interface epithelial ingrowth, absence of keratocytes, and an abnormality in the collagen structure of the donor homograft (lenticule) and abnormal host keratocytes in the recipient lamellar (host) bed. We suspect that the cause of keratocyte and collagen injury was associated with the cryopreservation process. We recommend that if a combined cataract extraction and keratophakia procedure is contemplated, the lens extraction be performed in an intracapsular fashion if the keratophakia procedure has been completed or in an extracapsular fashion before the replacement of the donor lenticule and anterior part of the host cornea.
我们研究了一枚人类角膜，该角膜是在角膜晶状体植入术和白内障摘除术后四个月进行穿透性角膜移植时获取的。我们发现存在内皮细胞丢失并伴有角膜水肿、界面上皮内生、角膜细胞缺失，供体同种异体移植片（晶状体）的胶原结构异常，以及受体板层（宿主）床中的宿主角膜细胞异常。我们怀疑角膜细胞和胶原损伤的原因与冷冻保存过程有关。我们建议，如果考虑进行白内障摘除与角膜晶状体植入联合手术，若角膜晶状体植入手术已完成，则晶状体摘除应以囊内方式进行；或者在植入供体晶状体和宿主角膜前部之前，以囊外方式进行晶状体摘除。
