凝集抗体在实验性隐球菌性脑膜炎中的作用
Influence of agglutinating antibody in experimental cryptococcal meningitis.
作者信息
Perfect J R, Lang S D, Durack D T
出版信息
Br J Exp Pathol. 1981 Dec;62(6):595-9.
Abstract
A model for chronic Cryptococcus neoformans meningitis in corticosteroid-treated rabbits was used to determine the influence of pre-formed agglutinating antibody to cryptococcal polysaccharide on the progress of this infection. Immunized rabbits developed serum agglutinating antibody with a geometric mean titre of 1:32, but none was detected in cerebrospinal fluid. Prior immunization did not enhance immunity to infection, had no effect on the number of viable cryptococci in cerebrospinal fluid, and did not prevent dissemination outside the central nervous system. Future investigations in this field should focus on cellular rather than humoral defence mechanisms.
摘要
在使用皮质类固醇治疗的兔子身上建立了慢性新型隐球菌脑膜炎模型，以确定预先形成的针对隐球菌多糖的凝集抗体对这种感染进程的影响。免疫后的兔子产生了血清凝集抗体，几何平均滴度为1:32，但脑脊液中未检测到。预先免疫并未增强对感染的免疫力，对脑脊液中活的隐球菌数量没有影响，也未能阻止中枢神经系统外的播散。该领域未来的研究应侧重于细胞而非体液防御机制。
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