凝集抗体在实验性隐球菌性脑膜炎中的作用
Influence of agglutinating antibody in experimental cryptococcal meningitis.
作者信息
Perfect J R, Lang S D, Durack D T
出版信息
Br J Exp Pathol. 1981 Dec;62(6):595-9.
Abstract
A model for chronic Cryptococcus neoformans meningitis in corticosteroid-treated rabbits was used to determine the influence of pre-formed agglutinating antibody to cryptococcal polysaccharide on the progress of this infection. Immunized rabbits developed serum agglutinating antibody with a geometric mean titre of 1:32, but none was detected in cerebrospinal fluid. Prior immunization did not enhance immunity to infection, had no effect on the number of viable cryptococci in cerebrospinal fluid, and did not prevent dissemination outside the central nervous system. Future investigations in this field should focus on cellular rather than humoral defence mechanisms.
摘要
在使用皮质类固醇治疗的兔子身上建立了慢性新型隐球菌脑膜炎模型，以确定预先形成的针对隐球菌多糖的凝集抗体对这种感染进程的影响。免疫后的兔子产生了血清凝集抗体，几何平均滴度为1:32，但脑脊液中未检测到。预先免疫并未增强对感染的免疫力，对脑脊液中活的隐球菌数量没有影响，也未能阻止中枢神经系统外的播散。该领域未来的研究应侧重于细胞而非体液防御机制。
相似文献
1
Influence of agglutinating antibody in experimental cryptococcal meningitis.凝集抗体在实验性隐球菌性脑膜炎中的作用
Br J Exp Pathol. 1981 Dec;62(6):595-9.
2
Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis.实验性隐球菌性脑膜炎中脑脊液的调理活性
Infect Immun. 1990 Jul;58(7):2115-9. doi: 10.1128/iai.58.7.2115-2119.1990.
3
[Clinical course of cryptococcosis in HIV infection].[HIV感染中隐球菌病的临床病程]
Klin Med (Mosk). 1999;77(1):39-42.
4
Cryptococcal meningitis; significance of positive antigen test on undiluted spinal fluid.隐球菌性脑膜炎；未稀释脑脊液抗原检测阳性的意义
N Y State J Med. 1981 Aug;81(9):1369-70.
5
Significance of antibody detection in the diagnosis of cryptococcal meningitis.抗体检测在隐球菌性脑膜炎诊断中的意义。
J Immunoassay Immunochem. 2012;33(2):140-8. doi: 10.1080/15321819.2011.606862.
6
Chronic cryptococcal meningitis: a new experimental model in rabbits.慢性隐球菌性脑膜炎：家兔新实验模型
Am J Pathol. 1980 Oct;101(1):177-94.
7
Effects of cyclosporine in experimental cryptococcal meningitis.环孢素在实验性隐球菌性脑膜炎中的作用
Infect Immun. 1985 Oct;50(1):22-6. doi: 10.1128/iai.50.1.22-26.1985.
8
Analysis of antibody response to Cryptococcus neoformans in five patients with AIDS and cryptococcosis by immunoblotting.通过免疫印迹法分析5例艾滋病合并隐球菌病患者对新型隐球菌的抗体反应。
J Infect. 2000 Jan;40(1):64-8. doi: 10.1053/jinf.1999.0592.
9
Diagnosis of cryptococcal meningitis.隐球菌性脑膜炎的诊断
JAMA. 1976 Nov 29;236(22):2517-8.
10
Cryptococcus neoformans-specific oligoclonal immunoglobulins in cerebrospinal fluid in cryptococcal meningitis.新型隐球菌性脑膜炎患者脑脊液中新型隐球菌特异性寡克隆免疫球蛋白
Lancet. 1977 Jun 11;1(8024):1262. doi: 10.1016/s0140-6736(77)92473-4.
引用本文的文献
1
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans.艾滋病时代的隐球菌病——新型隐球菌发现100年后
Clin Microbiol Rev. 1995 Oct;8(4):515-48. doi: 10.1128/CMR.8.4.515.
2
The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.编码磷酸核糖氨基咪唑羧化酶（ADE2）的基因对于新型隐球菌在脑脊液中的生长至关重要。
Infect Immun. 1993 Oct;61(10):4446-51. doi: 10.1128/iai.61.10.4446-4451.1993.
3
Pathogenesis of pulmonary Cryptococcus neoformans infection in the rat.大鼠肺新型隐球菌感染的发病机制
Infect Immun. 1994 Nov;62(11):4755-61. doi: 10.1128/iai.62.11.4755-4761.1994.
4
Variable efficacy of passive antibody administration against diverse Cryptococcus neoformans strains.针对不同新型隐球菌菌株的被动抗体给药的疗效差异
Infect Immun. 1995 Sep;63(9):3353-9. doi: 10.1128/iai.63.9.3353-3359.1995.
5
Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.新型隐球菌的毒力。二氧化碳对荚膜合成的调节。
J Clin Invest. 1985 Aug;76(2):508-16. doi: 10.1172/JCI112000.
6
Effects of cyclosporine in experimental cryptococcal meningitis.环孢素在实验性隐球菌性脑膜炎中的作用
Infect Immun. 1985 Oct;50(1):22-6. doi: 10.1128/iai.50.1.22-26.1985.
7
Protection of mice against experimental cryptococcosis by anti-Cryptococcus neoformans monoclonal antibody.抗新型隐球菌单克隆抗体对小鼠实验性隐球菌病的保护作用。
Infect Immun. 1987 Mar;55(3):749-52. doi: 10.1128/iai.55.3.749-752.1987.
8
Antibody-dependent natural killer cell-mediated growth inhibition of Cryptococcus neoformans.抗体依赖性自然杀伤细胞介导的新型隐球菌生长抑制
Infect Immun. 1986 Feb;51(2):556-62. doi: 10.1128/iai.51.2.556-562.1986.
9
Passive immunization against Cryptococcus neoformans with an isotype-switch family of monoclonal antibodies reactive with cryptococcal polysaccharide.用一组与新型隐球菌多糖反应的同型转换单克隆抗体对新型隐球菌进行被动免疫。
Infect Immun. 1990 Jun;58(6):1919-23. doi: 10.1128/iai.58.6.1919-1923.1990.
10
Opsonic activity of cerebrospinal fluid in experimental cryptococcal meningitis.实验性隐球菌性脑膜炎中脑脊液的调理活性
Infect Immun. 1990 Jul;58(7):2115-9. doi: 10.1128/iai.58.7.2115-2119.1990.
本文引用的文献
1
Passive immunization against Cryptococcus neoformans.针对新型隐球菌的被动免疫
Proc Soc Exp Biol Med. 1958 Jul;98(3):611-4. doi: 10.3181/00379727-98-24123.
2
Chronic cryptococcal meningitis: a new experimental model in rabbits.慢性隐球菌性脑膜炎：家兔新实验模型
Am J Pathol. 1980 Oct;101(1):177-94.
3
Determination of total and merecaptothanol-resistant antibody in the same serum sample.同一血清样本中总抗体和巯基乙醇抗性抗体的测定。
Clin Exp Immunol. 1970 Feb;6(2):313-6.
4
Experimental murine cryptococcosis: effect of hyperimmunization to capsular polysaccharide.实验性小鼠隐球菌病：对荚膜多糖进行超免疫的效果
J Immunol. 1967 May;98(5):914-22.
5
Prognostic factors in cryptococcal meningitis. A study in 111 cases.隐球菌性脑膜炎的预后因素。111例病例研究。
Ann Intern Med. 1974 Feb;80(2):176-81. doi: 10.7326/0003-4819-80-2-176.
6
Passively-acquired immunity in experimental cryptococcosis.
Sabouraudia. 1965 Jun;4(2):80-4. doi: 10.1080/00362176685190211.
7
Nature of the effector cells responsible for antibody-dependent cell-mediated killing of Cryptococcus neoformans.负责抗体依赖性细胞介导的新型隐球菌杀伤作用的效应细胞的性质。
Infect Immun. 1976 Sep;14(3):716-20. doi: 10.1128/iai.14.3.716-720.1976.
8
Cryptococcosis after renal transplantation: report of ten cases.肾移植后隐球菌病：10例报告
Surgery. 1976 Mar;79(3):268-77.
9
Experimental cryptococcosis in normal and B-cell-deficient mice.正常小鼠和B细胞缺陷小鼠的实验性隐球菌病
Infect Immun. 1979 Oct;26(1):1-3. doi: 10.1128/iai.26.1.1-3.1979.
10
Cryptococcus neoformans-specific oligoclonal immunoglobulins in cerebrospinal fluid in cryptococcal meningitis.新型隐球菌性脑膜炎患者脑脊液中新型隐球菌特异性寡克隆免疫球蛋白
Lancet. 1977 Jun 11;1(8024):1262. doi: 10.1016/s0140-6736(77)92473-4.
Zotero 插件