Zander A R, Spitzer G, Legha S, Dicke D A, Verma D S, Johnston D A, Vellekoop L, Beran M, Schell F, Minnhaar G, Blumenschein G R, Bodey G P
Cancer Treat Rep. 1982 Feb;66(2):385-6.
The feasibility of high-dose AMSA followed by autologous bone marrow rescue was studied in seven patients with solid tumors. They received a total of 12 courses of treatment. Total doses ranged from 600 to 1000 mg/m2/course. Major toxic effects were myelosuppression, fever of unknown origin, and stomatitis. One patient with malignant melanoma had stable disease lasting 2 months; the other six had progressive disease.
对7例实体瘤患者研究了大剂量氨甲喋呤（AMSA）后进行自体骨髓挽救的可行性。他们共接受了12个疗程的治疗。总剂量范围为600至1000mg/m²/疗程。主要毒性作用为骨髓抑制、不明原因发热和口腔炎。1例恶性黑色素瘤患者病情稳定持续2个月；其他6例病情进展。
