Sámal M, Kirschnerová Z, Jirkovský J, Foltýnová V, Dienstbier Z
Czech Med. 1981;4(4):224-30.
On the basis of a simple examination of the phagocytic activity of leukocytes of the peripheral blood., with the help of the yeast cells Saccharomyces cerevisiae, we determined the functional ability of leukocytes in untreated patients with the Hodgkin's disease, in the course of the primary chemotherapy, during the complete remission and in the relapse of the disease. In all the periods we found only changes in the absolute number of phagocytic cells, corresponding to the changes in the leukocyte count (increased numbers in untreated patients and in relapse, decreased number in the course of the chemotherapy). The value of the phagocytic and activity indices in untreated patients were only moderately reduced. In the course of chemotherapy there was a more remarkable drop of the phagocytic activity only in the first half of the treatment series. In the complete remission the phagocytic activity values were normal. We did not observe significant differences between clinical stages of the Hodgkin's disease in any group. Our results correspond to the clinical course of the disease (absence of infectious complications) in the patients followed. The presented conclusions do not concern bactericidal ability of leukocytes, which is not reflected by the test method used. The test described here does not provide more data for monitoring the clinical course and chemotherapy of Hodgkin's disease than do routine examinations of the erythrocyte sedimentation and white blood count.
基于对外周血白细胞吞噬活性的简单检测，借助酿酒酵母细胞，我们测定了未经治疗的霍奇金病患者、初次化疗期间、完全缓解期及疾病复发期白细胞的功能能力。在所有阶段，我们仅发现吞噬细胞绝对数量的变化，这与白细胞计数的变化相对应（未经治疗的患者和复发期数量增加，化疗期间数量减少）。未经治疗的患者吞噬及活性指数仅适度降低。化疗过程中，仅在治疗系列的前半段吞噬活性有更显著下降。完全缓解期吞噬活性值正常。我们未观察到任何组中霍奇金病临床分期之间的显著差异。我们的结果与所观察患者的疾病临床进程（无感染并发症）相符。所得结论与白细胞的杀菌能力无关，所使用的检测方法未体现这一点。此处描述的检测方法相较于红细胞沉降和白细胞计数的常规检查，并未为监测霍奇金病的临床进程和化疗提供更多数据。
