Hölscher A H, Altmannsberger M
Dtsch Med Wochenschr. 1982 Jan 15;107(2):51-4. doi: 10.1055/s-2008-1069870.
In a 67-year-old woman a tumour-like swelling developed at the site of repeated bilateral injections of procaine solution with polyvinylpyrrolidone as an additive. The histological picture of the removed tumour showed striking similarities to a malignant histiocytic tumour. The diagnosis was histiocytic inflammation due to polyvinylpyrrolidone storage. Retention of polyvinylpyrrolidone increases with increasing molecular weight and is dependent of the form of application. Treatment consists of removal of the storage focus, because polyvinylpyrrolidone maintains foreign-body reaction and absorption and storage in internal organs may cause further complications. Injectable drugs should not be used with polyvinylpyrrolidone as depot-carrier.
