良性和恶性皮肤病皮肤组织切片中的原位T淋巴细胞鉴定

In-situ T lymphocyte identification in cutaneous tissue sections of benign and malignant dermatoses.

作者信息

Chu A C, Fergin P E, MacDonald D M

出版信息

Histopathology. 1982 Jan;6(1):25-33. doi: 10.1111/j.1365-2559.1982.tb02699.x.

DOI:10.1111/j.1365-2559.1982.tb02699.x

Abstract

An indirect immunoperoxidase technique employing a specific anti-human T lymphocyte antiserum has been used to identify T lymphocytes in cutaneous tissue sections of various benign and malignant dermatoses. Skin biopsies from patients with histologically confirmed lichen planus, discoid lupus erythematosus, psoriasis, actinic keratosis, squamous cell carcinoma, Bowen's disease, keratoacanthoma, malignant melanoma, inflamed serborrhoeic warts, sarcoidosis, follicular lymphoma and multicentric reticulohistiocytosis were examined. T lymphocytes were found to be the predominant cell type in the cutaneous infiltrates of the majority of these dermatoses. However, only few T lymphocytes were identified in sarcoidosis where they tended to be restricted to the periphery of the epithelioid cell granulomas. Similarly, in the cutaneous infiltrates of follicular lymphoma and in a patient with multicentric reticulohistiocytosis, few T lymphocytes were identified.

摘要

一种采用特异性抗人T淋巴细胞抗血清的间接免疫过氧化物酶技术已被用于鉴定各种良性和恶性皮肤病皮肤组织切片中的T淋巴细胞。对组织学确诊为扁平苔藓、盘状红斑狼疮、银屑病、光化性角化病、鳞状细胞癌、鲍温病、角化棘皮瘤、恶性黑色素瘤、炎症性脂溢性疣、结节病、滤泡性淋巴瘤和多中心网状组织细胞增生症患者的皮肤活检标本进行了检查。发现T淋巴细胞是这些皮肤病大多数皮肤浸润中的主要细胞类型。然而，在结节病中仅鉴定出少数T淋巴细胞，它们往往局限于上皮样细胞肉芽肿的周边。同样，在滤泡性淋巴瘤的皮肤浸润中以及在一名多中心网状组织细胞增生症患者中，也仅鉴定出少数T淋巴细胞。