Oliver J A, Vinci J M, Bowden R E, Weinberger A B, Baer L, Keiser H R, Cannon P J
Nephron. 1981;29(3-4):110-6. doi: 10.1159/000182325.
Plasma renin activity and the urinary excretions of kallikrein, kinin, immunoreactive PGE (iPGE) and aldosterone were determined in 23 patients with progressive systemic sclerosis (PSS) on a fixed sodium and potassium intake who had no clinically apparent renal disease. Urinary excretions of kallikrein and kinin in the PSS patients were not significantly different from those of a group of sex and race-matched normal controls. In the female PSS patients urinary excretion of iPGE was also found to be normal. Upright PRA was appropriate for the urinary sodium excretion in 18 PSS patients (13 normotensive and 5 hypertensives) but was significantly elevated in the remaining 5 (all normotensive). The data suggest that the renal kallikrein-kinin and prostaglandin systems are unaltered in PSS patients without clinical evidence of renal disease.
在23例进行性系统性硬化症（PSS）患者中，测定了他们在固定钠钾摄入量且无明显临床肾病情况下的血浆肾素活性以及尿激肽释放酶、激肽、免疫反应性前列腺素E（iPGE）和醛固酮的排泄量。PSS患者的尿激肽释放酶和激肽排泄量与一组性别和种族匹配的正常对照者相比无显著差异。在女性PSS患者中，还发现iPGE的尿排泄量正常。18例PSS患者（13例血压正常者和5例高血压患者）的直立位血浆肾素活性（PRA）与尿钠排泄量相符，但其余5例（均为血压正常者）的PRA显著升高。数据表明，在无临床肾病证据的PSS患者中，肾脏激肽释放酶-激肽系统和前列腺素系统未发生改变。
