Minuto F, Barreca A, Ferrini S, Mazzocchi G, Del Monte P, Giordano G
Acta Endocrinol (Copenh). 1982 Feb;99(2):161-5. doi: 10.1530/acta.0.0990161.
GH responsiveness to insulin-induced hypoglycaemia and its circadian secretion were studied in a group of subjects in different pubertal stages. The GH peak after insulin was minimal in stage 1 boys (7.6 +/- 1.3 (SEM) ng/ml) and increased progressively, in parallel with pubertal maturation, reaching a maximum in the adult state (20 +/- 4.0 ng/ml); the basal value was superimposable in all groups studied. The circadian secretion showed a sleep-related surge which was almost identical in the different stages; however in pubertal stage 1 boys multiple secretory peaks were observed, mainly during waking hours. A statistically significant difference (P less than 0.05) was observed in the mean concentration recorded during the day with a maximum in stage 1 boys (2.7 +/- 0.2 ng/ml) and a gradual decrease to a minimum in adults (1.2 +/- 0.3 ng/ml). This pattern seems to suggest that pulsatile rhythm is present in boys, similar to that observed for gonadotrophins.
在一组处于不同青春期阶段的受试者中，研究了生长激素（GH）对胰岛素诱导的低血糖的反应及其昼夜分泌情况。胰岛素注射后，1期男孩的GH峰值最小（7.6±1.3（SEM）ng/ml），并随着青春期成熟而逐渐增加，在成年期达到最大值（20±4.0 ng/ml）；在所研究的所有组中，基础值是可叠加的。昼夜分泌显示出与睡眠相关的高峰，在不同阶段几乎相同；然而，在青春期1期男孩中观察到多个分泌峰，主要在清醒时间。在白天记录的平均浓度中观察到统计学上的显著差异（P<0.05），1期男孩的浓度最高（2.7±0.2 ng/ml），并在成年人中逐渐降低至最低值（1.2±0.3 ng/ml）。这种模式似乎表明男孩中存在脉冲节律，类似于促性腺激素所观察到的节律。
