Sondern W, Leube G
Med Klin. 1978 Oct 13;73(41):1432-6.
In an open controlled multicenter study the effectiveness of various dose levels of (+)-Cyanidanol-3 (Catergen) in patients suffering from chronic liver disease and treated over a period of 6 months is assessed. Subjective symptoms as fatigue, nausea, loss of appetite, vomiting and pruritus are positively influenced at all dose levels. A statistically significant fall of the transaminases SGOT, SGPT and gamma--GT however occurs only at a dosage of 6 tablets per day (3000 mg per day) of (+)-Cyanidanol-3, which cannot be demonstrated at a dose level of 3 X 1 tablet per day. Between the dosage of 2 X 3 or 3 X 2 tablets per day is no significant difference. Side effects due to therapy could not be observed.
在一项开放性对照多中心研究中，评估了不同剂量水平的（+）-儿茶素-3（卡特金）对慢性肝病患者进行为期6个月治疗的有效性。所有剂量水平对疲劳、恶心、食欲不振、呕吐和瘙痒等主观症状均有积极影响。然而，仅在每天服用6片（3000毫克/天）（+）-儿茶素-3时，转氨酶SGOT、SGPT和γ-GT才有统计学显著下降，而每天服用3片时未显示此效果。每天服用2×3片或3×2片之间无显著差异。未观察到治疗引起的副作用。
