Neutrophil antibodies: detection and clinical application.

This paper discusses the current knowledge of neutrophil antibodies. Its purpose is fourfold: to review the antigens which have been found in neutrophils; to outline the major methodologies used to examine neutrophil antigen-antibody systems; to show the importance of neutrophil antibodies in immune neutropenia and febrile transfusion reactions; and to discuss the role of neutrophil antigens and antibodies in bone marrow and organ transplantation as well as in granulocyte transfusions.