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Drug metabolites in renal failure: pharmacokinetic and clinical implications.

作者信息

Verbeeck R K, Branch R A, Wilkinson G R

出版信息

Clin Pharmacokinet. 1981 Sep-Oct;6(5):329-45. doi: 10.2165/00003088-198106050-00001.

DOI:10.2165/00003088-198106050-00001
PMID:7037261
Abstract
摘要

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Drug metabolites in renal failure: pharmacokinetic and clinical implications.肾衰竭中的药物代谢产物：药代动力学及临床意义
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2
Active drug metabolites and renal failure.活性药物代谢物与肾衰竭
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3
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Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.药理活性药物代谢物：治疗及毒性活性、人体血浆及尿液数据、肾衰竭时的蓄积情况
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Drug metabolism and active drug metabolites in renal failure.肾衰竭中的药物代谢与活性药物代谢物
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[Interaction of phenytoin with propranolol, procainamide and digoxin].
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本文引用的文献

1
Biotransformation and excretion of lorazepam in patients with chronic renal failure.慢性肾衰竭患者中劳拉西泮的生物转化和排泄。
Br J Clin Pharmacol. 1976 Dec;3(6):1033-9. doi: 10.1111/j.1365-2125.1976.tb00354.x.
2
Single- and multiple-dose kinetics of oral lorazepam in humans: the predictability of accumulation.口服劳拉西泮在人体中的单剂量和多剂量动力学：蓄积的可预测性。
J Pharmacokinet Biopharm. 1979 Apr;7(2):159-79. doi: 10.1007/BF01059736.
3
Persistence of antibiotics in blood of patients with acute renal failure. II. Chloramphenicol and its metabolic products in the blood of patients with severe renal disease or hepatic cirrhosis.
肾功能损害对口服去铁酮药代动力学的影响。
Br J Clin Pharmacol. 2016 Oct;82(4):994-1001. doi: 10.1111/bcp.13037. Epub 2016 Jul 18.
4
Pharmacokinetics and dosage adjustment in patients with renal dysfunction.肾功能不全患者的药代动力学与剂量调整
Eur J Clin Pharmacol. 2009 Aug;65(8):757-73. doi: 10.1007/s00228-009-0678-8. Epub 2009 Jun 20.
5
Mechanistic modelling of tesaglitazar pharmacokinetic data in subjects with various degrees of renal function--evidence of interconversion.替格列扎尔在不同程度肾功能受试者中药代动力学数据的机制建模——相互转化的证据
Br J Clin Pharmacol. 2008 Jun;65(6):855-63. doi: 10.1111/j.1365-2125.2008.03110.x. Epub 2008 Feb 21.
6
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.劳拉西泮在重症疟疾伴惊厥儿童中的药代动力学及临床疗效
Br J Clin Pharmacol. 2008 Jan;65(1):12-21. doi: 10.1111/j.1365-2125.2007.02966.x. Epub 2007 Jul 17.
7
Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients.危重症患者长期持续输注劳拉西泮和咪达唑仑的比较群体药代动力学
Br J Clin Pharmacol. 2004 Feb;57(2):135-45. doi: 10.1046/j.1365-2125.2003.01957.x.
8
Drug dosage in patients with renal failure optimized by immediate concurrent feedback.通过即时同步反馈优化肾衰竭患者的药物剂量。
J Gen Intern Med. 2001 Jun;16(6):369-75. doi: 10.1046/j.1525-1497.2001.016006369.x.
9
Pharmacokinetics of quinine in patients with chronic renal failure.慢性肾功能衰竭患者中奎宁的药代动力学。
Eur J Clin Pharmacol. 1996;49(6):497-501. doi: 10.1007/BF00195937.
10
The disposition of paracetamol and its conjugates during multiple dosing in patients with end-stage renal failure maintained on haemodialysis.
Eur J Clin Pharmacol. 1993;45(2):141-5. doi: 10.1007/BF00315495.
急性肾衰竭患者血液中抗生素的持续存在。II. 重症肾病或肝硬化患者血液中的氯霉素及其代谢产物。
J Clin Invest. 1959 Sep;38(9):1498-508. doi: 10.1172/JCI103928.
4
THE METABOLISM OF DIGOXIN IN NORMAL SUBJECTS.正常受试者体内地高辛的代谢
J Pharmacol Exp Ther. 1964 Aug;145:203-9.
5
The effect of N-demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse.N-去甲基化对小鼠体内吗啡、可待因和哌替啶某些药理作用的影响。
J Pharmacol Exp Ther. 1954 Oct;112(2):191-6.
6
Propranolol disposition in renal failure.肾衰竭时普萘洛尔的处置
Br J Clin Pharmacol. 1980 Dec;10(6):561-6. doi: 10.1111/j.1365-2125.1980.tb00511.x.
7
Decreased clearance of diflunisal in renal insufficiency--an alternative explanation.肾功能不全时双氯芬酸清除率降低——另一种解释。
Br J Clin Pharmacol. 1980 Aug;10(2):185-6. doi: 10.1111/j.1365-2125.1980.tb01744.x.
8
Pharmacokinetics of acebutolol in patients with all grades of renal failure.醋丁洛尔在各程度肾衰竭患者中的药代动力学
Eur J Clin Pharmacol. 1980 May;17(5):339-48. doi: 10.1007/BF00558446.
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Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient.
Clin Pharmacol Ther. 1980 May;27(5):665-70. doi: 10.1038/clpt.1980.94.
10
The effect of impaired renal function on the plasma concentration and urinary excretion of metoprolol metabolites.肾功能受损对美托洛尔代谢物血浆浓度及尿排泄的影响。
Clin Pharmacokinet. 1980 Mar-Apr;5(2):181-91. doi: 10.2165/00003088-198005020-00005.