免疫毒性测试的新方法。
New approaches to immunotoxicity testing.
作者信息
Archer D L
出版信息
Environ Health Perspect. 1982 Feb;43:109-13. doi: 10.1289/ehp.8243109.
Abstract
New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for an in vitro metabolic activation step coupled to other in vitro immunologic assays is discussed.
摘要
本文对免疫毒性测试的新方法进行了综述和讨论。介绍了一种在体内激活T细胞的方法，该方法避免了因体外有丝分裂原试验中遇到的活力效应而产生的假象。讨论了采用过继转移方法将体外操作的优势与体内功能试验相结合用于自然杀伤细胞的情况。还讨论了将体外代谢激活步骤与其他体外免疫学试验相结合的必要性。
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