过敏反应、环磷酸腺苷与组胺释放
Allergic reactions, cyclic AMP and histamine release.
作者信息
Skov P S, Geisler A, Klysner R, Norn S
出版信息
Experientia. 1977 Jul 15;33(7):965-6. doi: 10.1007/BF01951308.
PMID:70374
Abstract
Both isobutylmethylxanthine and theophylline increased the level cyclic AMP in the mast cell. Theophylline reduced the allergic histamine release, whereas isobutylmethylxynthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is too simple.
摘要
异丁基甲基黄嘌呤和茶碱均可提高肥大细胞中环磷酸腺苷（cAMP）的水平。茶碱可减少过敏性组胺释放，而异丁基甲基黄嘌呤则显著增强组胺释放。这表明肥大细胞中cAMP水平与组胺释放之间呈负相关的假设过于简单。
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