Matsumoto T, Shibata M
Immunology. 1982 Feb;45(2):293-301.
A synthetic serum thymic factor (FTS) augmented the lipopolysaccharide (LPS)-induced polyclonal B-cell responses in vitro of CBA/N mice and their F1 hybrids having an X-linked B-cell defect. For this augmentation, FTS should be injected in vivo. Splenic B cells derived from FTS-treated mice with the CBA/N defect were receptive to T-cell help from normal or immunodeficient mouse T cells. Thus, the inability of B cells from mice with the CBA/N defect to accept T -cell help may not be caused by an intrinsic T-cell defect, but by a functional B-cell defect that can be corrected by treatment with FTS in vivo. Spleen cells from ATXBM CBA/N mice treated with FTS 3 weeks after cell transfer did not increase the B-cell response. B cells from FTS-treated male F1 mice with the CBA/N defect still have characteristics of neonatal mouse B cells as revealed by inhibition with antimouse Ig and anti-Ia sera. These findings suggest that FTS may act on generation of a B-cell acceptor for T -cell help, rather than on the maturation of a B-cell subset.
一种合成血清胸腺因子（FTS）增强了脂多糖（LPS）诱导的CBA/N小鼠及其具有X连锁B细胞缺陷的F1杂种小鼠体外多克隆B细胞反应。为实现这种增强，FTS需进行体内注射。来自经FTS处理的有CBA/N缺陷的小鼠的脾B细胞对正常或免疫缺陷小鼠T细胞的T细胞辅助具有反应性。因此，CBA/N缺陷小鼠的B细胞无法接受T细胞辅助可能并非由内在的T细胞缺陷所致，而是由一种功能性B细胞缺陷引起，这种缺陷可通过体内FTS治疗得到纠正。细胞移植3周后用FTS处理的ATXBM CBA/N小鼠的脾细胞并未增强B细胞反应。如用抗小鼠Ig和抗Ia血清抑制所显示的那样，来自经FTS处理的有CBA/N缺陷的雄性F1小鼠的B细胞仍具有新生小鼠B细胞的特征。这些发现表明，FTS可能作用于T细胞辅助的B细胞受体的产生，而非作用于B细胞亚群的成熟。
