Kinney E L, Nicholas G G, Gallo J, Pontoriero C, Zelis R
J Clin Pharmacol. 1982 Jan;22(1):74-6. doi: 10.1002/j.1552-4604.1982.tb05712.x.
Verapamil was evaluated in 16 patients with severe Raynaud's phenomenon. Fifty per cent of patients experienced subjective improvement by history, but only one patient had a substantial reduction in the frequency of Raynaud's phenomenon as assessed by diary analysis. We conclude that verapamil is not effective in most patients with severe Raynaud's phenomenon.
对16例重度雷诺现象患者使用维拉帕米进行了评估。根据病史,50%的患者主观感觉有所改善,但通过日记分析评估,只有1例患者的雷诺现象发作频率大幅降低。我们得出结论,维拉帕米对大多数重度雷诺现象患者无效。