Ward M J, Roland J M, Banks D C
Postgrad Med J. 1981 Oct;57(672):633-4. doi: 10.1136/pgmj.57.672.633.
In a randomized cross-over trial the antihypertensive effect of metoprolol given once daily was compared with its effects after twice-daily dosage. Metoprolol given as a single morning dose had a useful antihypertensive effect for 24 hr and may be given in this way for the treatment of hypertension.
在一项随机交叉试验中,比较了美托洛尔每日一次给药的降压效果与其每日两次给药后的效果。早晨单次服用美托洛尔具有长达24小时的有效降压作用,可采用这种方式用于高血压治疗。