六种β受体阻滞剂和一种噻嗪类利尿剂治疗原发性高血压的随机研究。
Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension.
作者信息
Wilcox R G
出版信息
Br Med J. 1978 Aug 5;2(6134):383-5. doi: 10.1136/bmj.2.6134.383.
Abstract
Atenolol was compared with five other beta-blockers and a thiazide diuretic in a randomised cross-over trial of once-daily treatment of essential hypertension. Atenolol was significantly better at reducing resting and exercise blood pressures at 24 hours than any of the other drugs and had a low incidence of side effects. Both timolol and acebutolol had a significant hypotensive effect at 24 hours and a low incidence of side effects, suggesting that further increases in dosage might be effective and well tolerated. Labetalol proved ineffective when given once daily, and the high incidence of side effects, equalled only by pindolol, would probably prohibit further increases in dosage. Bendrofluazide was equal or superior to all the beta-blockers except atenolol at reducing resting blood pressure, and its cheapness still makes it an agent of first choice in mild or moderate essential hypertension.
摘要
在一项关于原发性高血压每日一次治疗的随机交叉试验中，阿替洛尔与其他五种β受体阻滞剂及一种噻嗪类利尿剂进行了比较。阿替洛尔在降低24小时静息血压和运动血压方面显著优于其他任何药物，且副作用发生率较低。噻吗洛尔和醋丁洛尔在24小时均有显著降压作用，副作用发生率低，这表明进一步增加剂量可能有效且耐受性良好。拉贝洛尔每日给药一次时被证明无效，其副作用发生率高（仅与吲哚洛尔相当），这可能会阻止进一步增加剂量。苄氟噻嗪在降低静息血压方面与除阿替洛尔外的所有β受体阻滞剂相当或更优，且价格便宜，这使其仍是轻度或中度原发性高血压的首选药物。
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本文引用的文献
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Renal circulatory responses to general anaesthesia in the rabbit: studies using radioactive microspheres.兔对全身麻醉的肾循环反应：使用放射性微球的研究
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The effect on blood pressure of beta-adrenoceptor blocking drugs administered once daily and their duration of action when therapy is ceased.每日服用一次的β-肾上腺素能受体阻断药物对血压的影响及其停药后的作用持续时间。
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