Wilcox R G
Br Med J. 1978 Aug 5;2(6134):383-5. doi: 10.1136/bmj.2.6134.383.
Atenolol was compared with five other beta-blockers and a thiazide diuretic in a randomised cross-over trial of once-daily treatment of essential hypertension. Atenolol was significantly better at reducing resting and exercise blood pressures at 24 hours than any of the other drugs and had a low incidence of side effects. Both timolol and acebutolol had a significant hypotensive effect at 24 hours and a low incidence of side effects, suggesting that further increases in dosage might be effective and well tolerated. Labetalol proved ineffective when given once daily, and the high incidence of side effects, equalled only by pindolol, would probably prohibit further increases in dosage. Bendrofluazide was equal or superior to all the beta-blockers except atenolol at reducing resting blood pressure, and its cheapness still makes it an agent of first choice in mild or moderate essential hypertension.
在一项关于原发性高血压每日一次治疗的随机交叉试验中，阿替洛尔与其他五种β受体阻滞剂及一种噻嗪类利尿剂进行了比较。阿替洛尔在降低24小时静息血压和运动血压方面显著优于其他任何药物，且副作用发生率较低。噻吗洛尔和醋丁洛尔在24小时均有显著降压作用，副作用发生率低，这表明进一步增加剂量可能有效且耐受性良好。拉贝洛尔每日给药一次时被证明无效，其副作用发生率高（仅与吲哚洛尔相当），这可能会阻止进一步增加剂量。苄氟噻嗪在降低静息血压方面与除阿替洛尔外的所有β受体阻滞剂相当或更优，且价格便宜，这使其仍是轻度或中度原发性高血压的首选药物。
