Ozimek C D, Grimson R C, Aylsworth A S
Teratology. 1982 Feb;25(1):53-9. doi: 10.1002/tera.1420250108.
Two hundred and eighty-five cases of TEF/EA occurring in North Carolina from 1952-1978 were reviewed. Except for a greater incidence of low-birth-weight infants and hydramnios during pregnancy, the cases appeared to be representative of the population. Clustering of cases over time was statistically confirmed. The cyclic variation suggested an association with an infectious agent. The variation of reported infectious hepatitis cases during the period of this study resembled the variation of TEF/EA cases that had no other documented congenital malformations.
回顾了1952年至1978年在北卡罗来纳州发生的285例食管闭锁/气管食管瘘病例。除了低体重儿发生率较高以及孕期羊水过多外，这些病例似乎代表了该人群。病例随时间的聚集在统计学上得到了证实。周期性变化提示与一种感染因子有关。在本研究期间报告的传染性肝炎病例的变化类似于那些没有其他记录在案的先天性畸形的食管闭锁/气管食管瘘病例的变化。
