Juret P, Couette J E, Delozier T, Le Talaer J Y
Bull Cancer. 1981;68(3):224-31.
In 96 patients (95 women--1 man) with osseous metastases from breast cancer suitable for analysis an objective remission was obtained with hydroxy-9-methyl-2-ellipticinium (100 mg/m2 weekly) in 31 cases. These responses lasted from 3 to 17 months. The main characteristic of this compound is its lack of marrow toxicity, a property of value in osseous lesions where marrow is so frequently involved, making difficult the use of conventional chemical drugs. The principal unpleasant drawback is an inhibition of the salivary secretion which causes other side effects such as tongue mycosis, anorexia, and asthenia. Less frequently immunologic disorders and a few cases of renal insufficiency were observed.
在96例适合分析的乳腺癌骨转移患者（95名女性，1名男性）中，31例使用羟基-9-甲基-2-椭圆玫瑰树碱（每周100mg/m²）获得了客观缓解。这些缓解持续3至17个月。该化合物的主要特点是缺乏骨髓毒性，这一特性对于骨髓经常受累的骨病变很有价值，使得传统化学药物难以使用。主要的不良缺点是抑制唾液分泌，这会导致其他副作用，如舌部霉菌感染、厌食和乏力。较少观察到免疫紊乱和少数肾功能不全病例。
