Boegman R J, Scarth B
Can J Physiol Pharmacol. 1982 Jan;60(1):41-6. doi: 10.1139/y82-005.
A peripheral nerve autograft placed on the surface of a normally innervated muscle has been shown to induce acetylcholine hypersensitivity and myofibrillar degeneration. Using a similar preparation, we determined the acid protease, alkaline protease, and N-acetylglucosaminidase activity in rat soleus muscle and the effect of protease inhibitors on these enzymes. Three days after nerve transplant, the muscle showed a significant increase in all three enzymes assayed. The protease inhibitors leupeptin and pepstatin totally prevented the nerve-induced increase in hydrolase activity. Our data suggest that muscle degeneration is secondary to an inflammatory response induced by the nerve.
已证明，置于正常神经支配肌肉表面的周围神经自体移植会诱导乙酰胆碱超敏反应和肌原纤维变性。我们采用类似的制备方法，测定了大鼠比目鱼肌中的酸性蛋白酶、碱性蛋白酶和N-乙酰葡糖胺酶活性，以及蛋白酶抑制剂对这些酶的影响。神经移植三天后，所检测的这三种酶在肌肉中的活性均显著增加。蛋白酶抑制剂亮抑酶肽和胃蛋白酶抑制剂完全抑制了神经诱导的水解酶活性增加。我们的数据表明，肌肉变性是神经诱导的炎症反应的继发结果。
