Petrie W M, Ban T A, Ananth J V
Int Pharmacopsychiatry. 1981;16(4):245-50. doi: 10.1159/000468501.
As part of the Canadian Mental Health Association Collaborative Study, the hypothesis that combined administration of nicotinic acid and pyridoxine has greater therapeutic effects than the component drugs in chronic schizophrenic patients was tested. This could not be substantiated in a 48-week study in which supplementation of neuroleptic treatment with a single vitamin, i.e., nicotinic acid or pyridoxine, produced significant therapeutic changes, while supplementation with both vitamins did not.
作为加拿大心理健康协会合作研究的一部分，研究人员对烟酸和吡哆醇联合给药比单一药物对慢性精神分裂症患者具有更大治疗效果这一假设进行了验证。在一项为期48周的研究中，这一假设未得到证实，该研究发现，在使用抗精神病药物治疗的基础上，单一补充维生素（即烟酸或吡哆醇）会产生显著的治疗效果，而同时补充两种维生素则不会。
