Solomon K R, Evans A A
Onderstepoort J Vet Res. 1978 Mar;45(1):39-41.
A total of 14 insect juvenile hormone mimics was tested for activity in Amblyomma hebraeum by exposing newly engorged larvae to filter paper impregnated with hormone mimics. The most active compounds used in this assay were HS 103 (6-ethyl-3-pyridyl geranyl ether; EC50=0,0018 mg/cm2), ZR 512 (Ethyl 3,7,11-trimethyldodeca-2,4-dienoate; EC50=0,0022 mg/cm2), HS 2 (6-methyl-3-pyridyl geranyl ether; EC50=0,0035 mg/cm2), ZR 615 (N-ethyl 3,7,11-trimethyldodeca-2,4-dieneamide; EC50=0,0035 mg/cm2), ZR 777 (Prop-2-ynyl 3,7,11-trimethyldodeca-2,4-dienoate; EC50=0,0039 mg/cm2) and ZR 515 (Isopropyl-11-methoxy 3,7,11-trimethyldodeca-2,4-dienoate; EC50=0,0094 mg/cm2). Activity in this assay was similar to that reported in insects and was consistent with the susceptibility of these compounds to metabolic inactivation. The results suggest that ZR 615 may be of possible use in tick control.
通过将刚饱血的幼虫暴露于浸渍有昆虫保幼激素类似物的滤纸上，对总共14种昆虫保幼激素类似物进行了在南非山蜱中的活性测试。该试验中使用的活性最高的化合物为HS 103（6-乙基-3-吡啶基香叶基醚；EC50 = 0.0018 mg/cm²）、ZR 512（3,7,11-三甲基十二碳-2,4-二烯酸乙酯；EC50 = 0.0022 mg/cm²）、HS 2（6-甲基-3-吡啶基香叶基醚；EC50 = 0.0035 mg/cm²）、ZR 615（N-乙基-3,7,11-三甲基十二碳-2,4-二烯酰胺；EC50 = 0.0035 mg/cm²）、ZR 777（2-丙炔基-3,7,11-三甲基十二碳-2,4-二烯酸酯；EC50 = 0.0039 mg/cm²）和ZR 515（11-甲氧基-3,7,11-三甲基十二碳-2,4-二烯酸异丙酯；EC50 = 0.0094 mg/cm²）。该试验中的活性与在昆虫中报道的活性相似，并且与这些化合物对代谢失活的敏感性一致。结果表明ZR 615可能可用于蜱虫控制。
