Whitehead S A, Pennington J M, Carter D A
J Endocrinol. 1982 Apr;93(1):75-81. doi: 10.1677/joe.0.0930075.
Changes in pituitary responses to pulses of LH releasing hormone (LH-RH) after ovariectomy in the rat have been investigated with an in-vitro perifusion system. On the third day after ovariectomy there was a large increase in the responsiveness of the pituitary gland to LH-RH compared with days 1 and 2 and this preceded the first significant rise in circulating concentrations of LH. Exaggerated responses were observed on all subsequent days tested (days 4, 6, 10, 18 and 28) although the size of the response on day 10 was significantly lower compared with days 6, 18 or 28. It is suggested that the early phase of increased pituitary responsiveness to LH-RH results from a rise in pituitary LH-RH receptors, which increases both the synthesis of LH and the response to exogenous LH-RH. The reduced LH response, measured on day 10, may correlate with an increase in the endogenous secretion of LH-RH and an imbalance between LH synthesis and secretion at this time.
利用体外灌流系统研究了大鼠卵巢切除术后垂体对促黄体生成素释放激素（LH-RH）脉冲反应的变化。卵巢切除术后第三天，与第一天和第二天相比，垂体对LH-RH的反应性大幅增加，且这一变化先于促黄体生成素（LH）循环浓度的首次显著升高。在随后所有测试日（第4、6、10、18和28天）均观察到反应增强，尽管第10天的反应幅度与第6、18或28天相比显著降低。提示垂体对LH-RH反应性增加的早期阶段是由于垂体LH-RH受体增加所致，这既增加了LH的合成，也增强了对外源性LH-RH的反应。第10天测得的LH反应降低可能与LH-RH内源性分泌增加以及此时LH合成与分泌失衡有关。
