It is well established that mycobacteria other than tubercle bacilli and M. leprae are important human pathogens. At least 15 species comprise all the presently known mycobacterial pathogens of man. Eleven species are potential pathogens because disease production often dependent on special factors of the human host. The comments include some characterization of the mycobacteria, especially of the potential pathogenic species. A summary of important nontuberculous mycobacterial diseases of man is presented.